A spongy monolith for bioseparations (SPM-Bio) is flexible porous separation medium made from a general-purpose polymer material, poly(ethylene-co-glycidyl methacrylate), which has been already manufactured at the factory level. The SPM is a high permeable separation medium involving huge through-pores of 5 μm- hundreds μm, which are much larger than existing separation media. Moreover, the SPM-Bio easily binds with wide range of protein ligands and functional groups due to existence of epoxide groups that are highly reactive on the surface of SPM media with NH2, SH, OH etc. Thus, arbitrary biomolecules can be immobilized to the surface of the SPM-Bio, and SPMs-Bio ensure to be new separation media for the next generation, especially for efficient bioseparations.