A spongy monolith for bioseparations (SPM-Bio) is a flexible porous separation medium made from a general-purpose polymer material, poly(ethylene-co-glycidyl methacrylate), which has been already manufactured at the factory level. SPM is a high permeable separation medium involving huge through-pores of 5 μm- hundreds μm, which are much larger than that of the existing separation media. Moreover, SPM-Bio easily binds with wide range of protein ligands and functional groups because of existence of epoxide groups that are highly reactive on the surface of the SPM media with NH2, SH, OH etc. Thus, arbitrary biomolecules can be immobilized on the surface of SPM-Bio. SPMs-Bio ensure to be new separation media for the next generation, especially for efficient bioseparations.