A spongy monolith  is a flexible porous separation medium made from poly(ethylene-co-glycidyl methacrylate), a general-purpose polymer material, that has been already manufactured at the factory level. The size of through-pores (5 μm- hundreds μm) of SPM, much larger than that of the existing separation media, realizes high permeable separations. Moreover, SPM easily binds with wide range of protein ligands and functional groups because of the epoxide groups existing on the SPM surface as the epoxide groups are highly reactive with NH2, SH, OH etc. Because of this, arbitrary biomolecules can be immobilized on the SPM surface without laborious work. SPM ensures to be a novel separation medium for the next generation.