A spongy monolith  is a flexible porous separation medium made from poly(ethylene-co-glycidyl methacrylate), a general-purpose polymer, that is already manufactured at an industrial scale. Its large through-pores (5 μm to several hundreds μm) , which are  significantly larger than those of conventional separation media, enable highly permeable separations. In addition, SPM easily binds with a wide range of protein ligands and other functional groups. This is due to the presence of reactive epoxide groups on the SPM surface, which readily react with functional groups such as NH2, SH, OH. As a result, arbitrary biomolecules can be immobilized on the SPM surface without complicated procedure. These features make SPM a promising next-generation separation medium.