Physical Features

  1. High-throughput separations enabled by large through-pores, allowing high flow rate at low pressure
  2. Superior separation of large biomolecules (e.g., proteins, cells) to particle-packed media
  3. High-density immobilization of affinity ligand via reactive epoxide groups  on the SPM surface
  4. Extremely low irreversible adsorption of biomolecules after immobilization
  5. Excellent formability, enabling integration with various devices and existing systems 

Appearance and Pore Structure of the Spongy Monolith

(a) 4.7 mm o.d., (b) 30 mm o.d.

SEM image (× 500)

Average pore size: 10.5 µm

Chemical Features

  1. Enables various modifications via hydroxy or epoxide groups on the SPM surface
  2. Retains the functions of biomolecules (enzymes, antibodies, lectins) immobilized on the SPM surface
  3. Exhibits high resistance to alkaline conditions
  4. Lighter than conventinal separation media and easy to scale up
  5. Can be disposed of by incineration

Chemical structure of the spongy monolith

Monolithic separation media with large through-pores can be fabricated from thermoplastic polymers such as PEGM poly(ethylene-co-glycidyl methacrylate), which contains reactive epoxide group, and EVA poly(ethylene-co-vinyl acetate), which has acetic acid vinyl structures, as well as other  similar materials.

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