Physical Features

  1. High-throughput separations with large through-pores allowing the high flow rate at lower pressure
  2. Superior separation of large biomolecules (such as proteins, cells) to particle packed separation media
  3. Directly bindable with affinity ligands at high densities due to epoxides on the surface of the SPM (SPM-Bio)
  4. Extremely low irreversible adsorption of biological analytes after immobilization of biomolecules (SPM-Bio)
  5. Available to place into specific devices and existing parts with high formability

An appearance of the spongy monolith and pore structures

Chemical Features

  1. Possible various modifications through hydroxy or epoxide groups on the SPM surface
  2. Retaining functions of biomolecules (enzyme, antibody, lectin etc.) immobilized on the SPM surface (SPM-Bio)
  3. High resistance against alkaline condition
  4. Lighter than present separation media and easy to scale up
  5. disposable by incineration

Chemical structures of the spongy monolith

Monolithic separation media with large through-pore can be fabricated using PEGM poly(ethylene-co-glycidyl methacrylate) including reactive epoxide group, EVA poly(ethylene-co-vinyl acetate) having acetic acid vinyl structures and many other thermoplastic polymers as materials.

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