Physical Features
- 1. High-throughput separations with large through-pores allowing the high flow rate at lower pressure
- 2. Superior separation of large biomolecules (such as proteins, cells) to particle packed separation media
- 3. Directly bindable with affinity ligands at high densities due to epoxides on the surface of the SPM (SPM-Bio)
- 4. Extremely low irreversible adsorption of biological analytes after immobilization of biomolecules (SPM-Bio)
- 5. Available to place into specific devices and existing parts with high formability
An appearance of the spongy monolith and pore structures
Chemical Features
- 1. Possible various modifications through hydroxy or epoxide groups on the SPM surface
- 2. Retaining functions of biomolecules (enzyme, antibody, lectin etc.) immobilized on the SPM surface (SPM-Bio)
- 3. High resistance against alkaline condition
- 4. Lighter than present separation media and easy to scale up
- 5. Disposable by incineration
Chemical structures of the spongy monolith
Monolithic separation media with large through-pore can be fabricated using PEGM poly(ethylene-co-glycidyl methacrylate) including reactive epoxide group, EVA poly(ethylene-co-vinyl acetate) having acetic acid vinyl structures and many other thermoplastic polymers as materials.
